Glioblastoma accounts for 15 to 20% of brain tumors. Its average survival is 18 months. 70% of glioblastomas occur between 45 and 70 years old. Glioblastomas predominate in men in a ratio of 1.5 to 1.8 / 11.
Glioblastoma is the most common brain tumor in adults (Figure 1) with an annual incidence of 3.0 to 3.6 cases per 100,000, corresponding to 240,000 new cases per year worldwide. Ranked grade IV glioma by the World Health Organization (WHO), its prognosis is poor, with a 5-year survival rate of 3%.
Nearly 90% of glioblastomas are primary tumors (de novo), characterized by a short clinical history (<3 months) with no precedent of glioma; the remaining 10% are secondary to the anaplastic transformation of an infiltrating Grade II or III glioma.
Histologically, we find a neo-angiogenesis, known to be an important element of aggressiveness of these tumors, reflecting their degree of malignancy. These new vessels are abnormal, fragile and permeable, contributing to peritumoral edema and increased risk of bleeding.
Imaging plays a central role in the diagnosis and follow-Glioblastoma up of glioblastomas. In 1990, Macdonald introduced the first classification, revised and now improved by the RANO criteria ("Revised Assessment in Neuro-Oncology") in 2010.